Zetterberg began the 2007–08 season with a 16-game point-scoring streak, breaking the record of 14 games set by former Red Wing Norm Ullman in 1960. He was voted to start for the Western Conference in the 2008 NHL All-Star Game alongside teammates Chris Osgood, Lidström, and Pavel Datsyuk, but again did not play in the game due to back problems. Despite missing time due to injury, Zetterberg recorded a career-year with personal bests of 43 goals, 49 assists and 92 points in 75 games. He went on to add a 27 points in 22 playoff games, leading the Red Wings to the 2008 Stanley Cup championship, their 11th in team history. In game six of the Finals against the Pittsburgh Penguins, Zetterberg scored the Stanley Cup-winning goal and was awarded the Conn Smythe Trophy as playoffs MVP. His 13 playoff goals tied with teammate Johan Franzén for the Red Wings record for most in a single postseason. At the end of the season, Zetterberg was also up for the Frank J. Selke Trophy as the best defensive forward, but finished as a runner-up to Datsyuk.